Electrochemistry of copper efflux oxidase-like multicopper oxidases involved in copper homeostasis

Multicopper oxidases are widely studied enzymes catalyzing the oxygen reduction reaction. Among this family, one class belongs to copper efflux oxidases. They far less in bioelectrochemistry mainly because of low potential at which they reduce O2. However, presence a specific domain rich methionine residues covering first electron acceptor induces fundamental issues regarding transfer pathway. In addition, as involved homeostasis, understanding their catalytic mechanism may have important consequences therapeutic applications. We present here last findings reported on based electrochemical tools. focus proposed roles methionine-rich process. Especially, binding and interfacial process appear be two aspects discuss.